Technical Details of SCHOTT Reagent Blister
Reagent Blisters are an advanced solution designed to simplify workflows, enhance reagent stability, and optimize diagnostic consumables. Leveraging high-barrier materials and precision manufacturing, this technology ensures reagents remain stable over extended periods, even in challenging environments. It provides controlled reagent releases using piercing mechanisms, reducing the risk of contamination and enabling consistent results.
Quality and scalability
Backed by SCHOTT MINIFAB’s expertise, this technology supports seamless scaling from prototyping to mass production, ensuring your consumables meet both performance and commercial objectives.
SCHOTT MINIFAB has in-house, scalable, automated form-fill-seal-shear capability to manufacture reagent blisters in ISO7 equivalent facility. The capability is suited to supply hundreds to millions of blister per annum. Our standard format tooling expedites development. Full customization of volume and shape can be provided if required.
Compatible reagents
1. Enzymes - applied in diverse biological and chemical reactions.
2. Buffers - Lysis Buffers facilitate cell lysis and nucleic acid extraction. Wash Buffers aid in cleaning and preparing samples.
3. Chemical Reagents - Staining Solutions support cell and tissue analysis, while Solvents assist in sample preparation and processing.
4. Detection Reagents - Fluorescent Dyes enable assays for detecting specific molecules and Chemiluminescent Substrates are used for enzyme-linked immunosorbent assays (ELISAs)
5. Antibodies and Antigens - employed in diagnostic and research applications to detect and measure target molucules.
Don't see your reagent?
Talk to our team about our previous experience and what we can offer to derisk your integration. The sampling process takes 2 weeks from reagent receipt on our site to shipping of blisters to your site. Get in contact
Proven shelf life: A case study in blister reagent storage and functionality
This accelerated stability data gives confidence in the reliability of SCHOTT Reagent Blister technology for IVD applications. By demonstrating proven performance over 2.7 years of accelerated testing, we highlight the durability, functionality, and long-term consistency of our reagent packaging solution—key factors in successful diagnostic product development.
Data has shown chromogenic reagents stored within SCHOTT MINIFAB blisters on a consumable IVD remained functional and exceeded acceptance criteria after 2.7 years in accelerated stability study.
Blisters showed no evidence of common failure modes such as fluid loss, degredation of blister material or degredation of reagent at the final time point.
The solution: SCHOTT Reagent Blister
| Technical Data | |
|---|---|
| Shelf life | Up to 24 months (reagent dependent) |
| Chemical compatibility | Market leading chemical compatibility (reagent dependent) |
| Materials | High gas barrier chemical and biologically compatible material |
| Volumes (empty) | 72 - 2400ul (see standard blisters for details). Custom development available |
| Cost | Price dependent on reagent (consituent and volume), supply volumes, QC/QC requirements, standard or custom offering, foil materials |
| Quality assurance | Inline 100% mass and visual QC Leak testing, force gauge, vision systems |
| Quality control | Aging studies, functional assays, various analytical studies (e.g. HPLC, mass spec, flow cytometry) |
| Scalability | 100s to millions per annum |
| Filling accuracy | ≈ 0.3% |
| Reagent preparation | In house reagent preparation and management team |
| Supply chain and logistics | In house Supply Chain and Logistics team |
| Sampling process | Timeline - ≈ 2 weeks (from receipt of reagent arrival to shipping) Output - 50 sample blisters of single reagent" |
Want to know more? Let's talk
Whether you need more information, samples, a quote, or advice for a project, I would be delighted to talk to you.
