EVERIC® care

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€748.00 /Tray

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Your all-rounder

With an inner Si-O-C-H coating, EVERIC® care offers a barrier against glass leachables, even for formulations in high pH. Since leaching from the container can compromise the shelf life of sensitive drugs, these vials are the ideal packaging solution.

In addition, thanks to its hydrophobic inner surface, EVERIC® care reduces the residual volume when emptying the vial. This results in no need to overfill the vials and and increased dosage accuracy.

Studies have also shown that EVERIC® care care can be of advantage when it comes to adsorption of LNPs (Lipid Nano Particles) after freeze-thaw cycles.

Properties

Increased shelf life for highly sensitive drug formulations in high pH
Potentially reduced adsorption of LNPs after freeze-thawing-cycles
Lower residual volume leads to cost reduction due to decreased (less or no overfilling required) as well as increased dosage accuracy.
Portfolio range: ISO 2 ml - 50 ml*
Product manufactured according to relevant international norms and standards
Product registered at Regulatory Authorities as e.g. US FDA and China NMPA (and available for Pharmaceutical Registration Applications)

*(Discuss the availability of other formats with your local SCHOTT representative and the availability of ready-to-use formats (SCHOTT adaptiQ®) – coming soon)

Chemical Resistance

The stability of this layer during storage has been proven with different fillings in high pH by accelerated aging at 40 °C
For production control, the standard hydrolytic resistance test is supplemented by a dedicated release test, proving the coating's stability in high pH. Therefore the vials are two-times autoclaved: first, filled with 0.005 M KOH (pH 11.7 at start). Second, filled with 0.1 M HCI (pH 1 at start). A limit value of leached Sodium (Na) is defined per format.
In addition, a statistical drain-off test is performed to check the specified hydrophobicity of EVERIC® care vials.

Dimensions & Cosmetics

• Tight geometric tolerances thanks to 100% camera inspection of dimensional and cosmetic parameters along the process line.
• Strict AQLs, as dimensions and cosmetic defects are a key part of the product specification. Any containers with critical defects are classified as "not allowed in the lot".

Possible Applications

Proteins
The inner coating of EVERIC® care vials keeps leachable-sensitive proteins stable, even in high pH and improves residual emptying, especially relevant for low-fill volumes.

LNPs
The Si-O-C-H coating led to a reduced adsorption of lipid nano particles.

Enzymes and sensitive formulations
Metal ion leaching from the glass is fully minimized and under control, such that the reactivity of enzymes and sensitive formulations can be stabilized, even for formulations in the alkaline pH range.

Radiopharma
Stabilization of leachable-sensitive radiomolecules as well as potentially less adsorption.

Pure substances
As the Si-O-C-H coating is chemically inert, highly pure substances are preserved over long stocking periods, even if in high pH.

Advantages

Increased shelf-life stability for sensitive drug formulations in high pH
Minimized adsorption of LNPs after freeze-thaw cycles
Reduced residual drug volumes and therefore higher dosing accuracy after reconstitution

Data sheet

Datasheet EVERIC care

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