ViewPort® and ViewCell™
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Technical Details of ViewPort® and ViewCell™

The ViewPort® bioreactor port and ViewCell™ flow cell for biomanufacturing feature sealed optical windows that allow the use of outside optical sensors to monitor various bioprocessing steps. These interfaces are designed for easy integration into existing bioprocessing equipment to enable sterile in-situ measurements. The SCHOTT® PAT components are made of materials that follow pharmaceutical industry best practices, which is advantageous for qualification.

Enabling measurements while maintaining a sterile boundary

Safe and flexible use of sensors

Because the SCHOTT® sensor interfaces are the only wetted parts, optical measurements can be conducted in-situ while remaining contactless. Using SCHOTT’s PAT components eliminates the need to sterilize the sensor probe. This contributes not only to operational efficiency but can also help with qualification.

Sterilizable

The ViewPort® and ViewCell™ increase efficiency by eliminating the need to sterilize the sensor probe. SCHOTT’s process analytical components can be sterilized using all standard methods, like γ-radiation or steam in place (SIP). The ViewPort® can be sterilized with the entire bioreactor, and the ViewCell™ flow cell can be sterilized with processing piping and other equipment.

Excellent optical properties

The high-quality optical windows used in SCHOTT’s sensor interfaces enable precise transmission of optical signals between sensors and analytes.

Approved materials

The ViewPort® and ViewCell™ PAT components conform to applicable pharmaceutical regulations and guidelines. All components are manufactured using metal, glass, sapphire, and other materials in accordance with the pharma industry’s best practices.
Specifications
Monitoring results
Optical performance

Specifications

The SCHOTT® process analytical technology components maintain safe integrity for the long-term and help prevent contamination thanks to our advanced glass-to-metal seal technology.

 

 ViewPort® PG13.5

 ViewPort® Ingold (G 1 ¼ ")

 ViewPort® Single Use

 ViewCell™

 Raman spectroscopy

✓

 ✓

 ✓

 ✓

 Fluorescence spectroscopy

 ✓

 ✓

 ✓

 ✓

 UV / VIS / NIR

 ✓

 ✓

 ✓

 ✓

 Autoclaving / SIP / CIP

 ✓

 ✓

 -

 ✓

 Gamma-resistant

 ✓

 ✓

 ✓

 ✓

 Body material stainless steel 316L

 ✓

 ✓

 -

 ✓

 Body material PE (USP Class VI)

 -

 -

 ✓

 -

 Sapphire optical window

 ✓

 ✓

 ✓

 ✓

Monitoring results

ViewPort® sensor interface usage example: Chemometric for In-Situ Raman monitoring. 

Graph showing the raw data from in-situ Raman monitoring using SCHOTT ViewPort™ for Bioprocessing on the left and Chemometric result of different component concentration from raw data of in-situ Raman monitoring using SCHOTT ViewPort™ on the right

High-performance optical measurements 

Raman spectrum of H2O (532 nm) with ViewPort® sensor interface (dark blue) and without (turquoise).

 
Graph showing the Raman spectrum of water with and without a ViewPort® sensor interface

Want to know more? Let's talk

Whether you need more information, samples, a quote, or advice for a project, I would be delighted to talk to you.

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Christian Ott, Manager R&D Biotech and Life Sciences
Christian Ott

Head of R&D Biotech